MaineHealth Let’s Go! Shorts Video Series
Obesity Genetics & Epigenetics | Episode 3
Genes and obesity | CDC
https://www.cdc.gov/genomics/resources/diseases/obesity/obesedit.htm
Genetic Syndromes Associated with Obesity | Clinical Gate
https://clinicalgate.com/genetic-syndromes-associated-with-obesity/
What is Epigenetics? | CDC
https://www.cdc.gov/genomics/disease/epigenetics.htm
Nutrition in the First 1000 Days: Ten Practices to Minimize Obesity Emerging from Published Science | NIH
https://pubmed.ncbi.nlm.nih.gov/29194402/#article-details
0:00 – Welcome
0:41 – Genetics of Obesity
1:24 – Single Gene Defects
2:20 – Genes associated with obesity
2:51 – Genetic syndromes associated with obesity
3:28 – Epigenetics
4:22 – Tale of 2 Siblings
5:10 – Next Steps Video Rating: / 5
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The genetics of obesity.
Recently I have been tagged in a lot of videos from people disregarding the role that genes have when it comes to your body weight.
They often use false dichotomies, like ‘no, it is not your genes, you are eating too much’ which grossly misrepresents the role that genes play.
It isn’t your genes *or* how much you eat, it is more like *how* your genes influence how much you eat.
So, let’s talk about some basic genetic concepts and how they are involved with body weight regulation.
P.S. My new book ‘Everything Fat Loss’ is currently on sale at Amazon with an additional 10% and 22% discount in the .com and .co.uk markets. Feel free to grab it before the price goes up.
References:
– The body-mass index of twins who have been reared apart
– A twin study of human obesity
– New advances in the genetics of early onset obesity
– Positional cloning of the mouse obese gene and its human homologue
– Congenital leptin deficiency is associated with severe early-onset obesity in humans
– Lessons from extreme human obesity: monogenic disorders
– The genetics of obesity: from discovery to biology
– Variability in the heritability of body mass index: a systematic review and meta-regression Video Rating: / 5
In this episode, Dr. Stephanie Estima and Matt Maruca discuss the impact of light on our natural rhythms, emphasizing the importance of sunlight and the consequences of an indoor lifestyle. They challenge misconceptions about the sun and explore the connection between light, health, and hormonal balance.
Links mentioned:
Go to https://raoptics.com/drstephanie and use code: DRSTEPHANIE to get 10% off all Ra Optics products.
Lux Light Meter Pro – https://apps.apple.com/app/lux-light-meter-pro/id1292598866
Sunscreen makers withdraw products found to contain cancer-causing substance – https://www.health.harvard.edu/staying-healthy/sunscreen-makers-withdraw-products-found-to-contain-cancer-causing-substance
Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411113/
Episode Overview:
0:00:01 Cells communicate with ultraviolet light and its paradoxical nature
0:03:15 Opening dialogue with guest on circadian and infradian misalignment
0:06:59 Understanding the concept of full spectrum light and its importance
0:10:10 The Power of Light in Evolution and Life
0:13:30 Understanding the Role of Blue Light and UV Light
0:19:17 The Disruption of Indoor Living and Lack of Blue Light
0:22:28 The Misconceptions and Dangers of Sunscreen
0:28:28 Sunscreen: Is it Really Necessary?
0:32:53 The Role of Melanocytes Stimulating Hormone (MSH) in Sun Protection
0:37:10 Harmful Chemicals and Seed Oils: A Cancer Connection
0:44:52 Sunning the Perineum: A Hormone Augmentation Technique?
0:46:05 The Fall of Clothing and the Nudist Perspective
0:54:02 Leptin Resistance and Disruption of Circadian Rhythm
1:00:06 Impact of Contact Lenses and Corrective Surgery on Vision
1:03:12 Epigenetic modification: Understanding the impact of genes on vision
1:06:29 Moonlight and its potential influence on menstrual cycles
1:11:30 The Influence of Outdoor Time on Menstrual Cycle Alignment
1:14:30 The Benefits of Blue Light Blocking Glasses
1:20:07 Using Red Lenses for Nighttime Protection
Follow Me On Instagram: https://www.instagram.com/dr.stephanie.estima
Get yourself a copy of my best-selling book, The Betty Body: https://bettybodybook.com Video Rating: / 5
Watch the full episode and view show notes here: https://bit.ly/3OvetB5
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About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
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Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user’s own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies. Video Rating: / 5
Can obesity be genetic? What causes obesity? Top endocrinologist Dr Barbara McGowan explains the complex causes of obesity.
Learn more about obesity and/or make an appointment with Dr McGowan here: https://www.topdoctors.co.uk/doctor/barbara-mcgowan
Is obesity in our genes? Dr. Elizabeth Speliotes, M.D., Ph.D., M.P.H., explains the role genes play in body size and shape.
By analyzing genetic samples of 300,000 individuals across the globe, researchers have found more than 100 locations across the genome linked with obesity traits. These genetic clues may one day help doctors tailor the advice they give to patients about obesity complications. The study was published in the 12 Feb. issue of Nature. Video Rating: / 5
Obesity. It’s a global epidemic that now kills more people than malnutrition. Physiologists work to unravel the causes of obesity and the genetic factors involved.
Subscribe to our channel and follow us on Instagram (https://instagram.com/thephysoc), Twitter (https://twitter.com/ThePhySoc ) & Facebook (https://www.facebook.com/physoc), to keep up with the science of life.
Produced by Orinoco Communications for The Physiological Society
Animation: Hayley Evenett
Illustration: Alex Scarfe
Sound Design/Music: Alexander Bradley
Narration: Elisa Canas
Director: Peter Barker
Scientific advisor: Jeffrey M Friedman
Producer at The Physiological Society: Rachel Wheeley
Transcript:
Sometimes it seems like everywhere we look we’re exposed to adverts about dieting, urging us to lose weight.
Globally, the diet industry rakes in over £150 billion a year, and that figure is rising fast.
But, at the same time, worldwide obesity levels are also growing, and that matters, because obesity now kills more people than malnutrition.
So, what’s going on? Why are self-control and dieting alone unable to stop the growing obesity epidemic?
Research by physiologists suggests there are important biological factors at play.
Namely, that some of us are simply more genetically predisposed to become obese than others.
The root causes of obesity can be summed up like this: food intake, minus energy burned, equals fat stored.
So, obesity occurs when we consume more than we burn, and fat mass builds up.
But what happens when genetics are thrown into the mix?
Our understanding of this field has been advanced by scientific experiments involving a species of obese mouse.
These mice are always hungry and won’t stop eating. They never feel full.
The mice weigh three times more than normal mice because of a defect in a single gene.
Scientists identified that gene as one that codes for a hormone called leptin.
Leptin is made by fat cells and signals to the brain how much fat mass is in the body.
Without it, the brain mistakenly believes the body is starving, so the mice keep eating, even though they’ve had enough food.
Scientists translated this finding to humans when a four-year-old boy with the same genetic mutation became severely obese.
With regular leptin injections, his over-eating stopped and, by the age of eight, he was no longer overweight.
Studies of twins have helped us to identify the genetic basis of obesity.
Identical twins who come from the same egg and the same DNA have very similar body sizes.
But twins that come from different eggs show much more variability.
These studies show that while single genes are occasionally responsible most obesity cases are caused by a combination of genes working together.
Understanding the causes of obesity is far from simple but genetic factors such as leptin play an important role to regulate food intake and body weight.
So self-control alone is rarely enough to overcome the powerful effect of genes.
That’s why physiologists are working hard to assess how a healthy diet and exercise, combined with a better understanding of how genes influence obesity, can help turn the tide on this global epidemic.
A visual breakdown of why some individuals are resistant to maintaining weight loss through diet and exercise alone.
