MaineHealth Let’s Go! Shorts Video Series
Obesity Genetics & Epigenetics | Episode 3

Genes and obesity | CDC
https://www.cdc.gov/genomics/resources/diseases/obesity/obesedit.htm

Genetic Syndromes Associated with Obesity | Clinical Gate
https://clinicalgate.com/genetic-syndromes-associated-with-obesity/

What is Epigenetics? | CDC
https://www.cdc.gov/genomics/disease/epigenetics.htm

Nutrition in the First 1000 Days: Ten Practices to Minimize Obesity Emerging from Published Science | NIH
https://pubmed.ncbi.nlm.nih.gov/29194402/#article-details

0:00 – Welcome
0:41 – Genetics of Obesity
1:24 – Single Gene Defects
2:20 – Genes associated with obesity
2:51 – Genetic syndromes associated with obesity
3:28 – Epigenetics
4:22 – Tale of 2 Siblings
5:10 – Next Steps
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In this video, Drs. Baraki and Feigenbaum discuss how genes and environment influence the risk of obesity.

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Complete video at: http://fora.tv/2010/03/09/Hardwired_for_Life

Cognitive behavioral therapist Kristene Doyle argues that while genes may predispose us to anxiety or alcoholism, we still have final control over our thoughts, feelings and behaviors. “Regardless of one’s genetic predispositions, there needs to be accountability for one’s actions,” she says.

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Researchers in the field of behavioral genetics have asserted claims for a genetic basis to numerous behaviors, including homosexuality, aggression, alcoholism, and nurturing. Furthermore, a growing scientific and popular focus on genes and behavior has contributed to a resurgence of behavioral genetic determinism — the belief that genetics is the major factor in determining behavior. Just recently commentators have blamed the international economic crisis on the innate greed of our consumer “have it all now” society.

Are behaviors inbred, written indelibly in our genes as immutable biological imperatives, or is the environment more important in shaping our thoughts and actions? What are the social consequences of genetic diagnoses of such traits as intelligence, criminality, or homosexuality? How much of our behavior can be attributed to our hardwiring? – NY Salon

Dr. Kristene Doyle is the Associate Executive Director of the Albert Ellis Institute. She is also the Director of Clinical Services and Director of Child and Family Services at the Ellis Institute and an Adjunct Assistant Professor at St. John’s University.

She received her Ph.D. in clinical and school psychology from Hofstra University and a Doctor of Science degree from the International Institute for the Advanced Studies of Psychotherapy and Applied Mental Health. She has conducted seminars and workshops and given numerous presentations, both nationally and internationally, on Rational Emotive Behavior Therapy and its application to various mental disorders, including anxiety and depression.

Dr. Doyle has also appeared frequently on TV and radio and in newspapers across the country.
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Genetic testing is becoming more widely available and affordable, allowing individuals to learn more about their genetic makeup and potential health risks. This has implications for personalized medicine and disease prevention. Advances in genome sequencing technology have made it possible to sequence entire genomes in a matter of days or weeks, providing researchers with unprecedented insights into the genetic basis of disease and other biological processes.
#crispr #DNA #homozygous #genomics #GeneTherapy

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Jonathan Sebat, PhD, Director, Beyster Institute for Psychiatric Genomics, Professor of Psychiatry, Cellular & Molecular Medicine, and Pediatrics, UC San Diego School of Medicine joins William Mobley, MD, PhD to discuss genetics as they relate to autism and how technology can help pinpoint the genes contributing to the disorder. Watch the Entire Talk Here: https://www.youtube.com/watch?v=hjeBM95Nft0&t=15s [11/2017] [Show ID: 33065]

Please Note: Knowledge about health and medicine is constantly evolving. This information may become out of date.

More from: Autism – The Brain Channel
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UCTV features the latest in health and medicine from University of California medical schools. Find the information you need on cancer, transplantation, obesity, disease and much more.

UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California — teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
(https://www.uctv.tv)
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The genetics of obesity.

Recently I have been tagged in a lot of videos from people disregarding the role that genes have when it comes to your body weight.

They often use false dichotomies, like ‘no, it is not your genes, you are eating too much’ which grossly misrepresents the role that genes play.

It isn’t your genes *or* how much you eat, it is more like *how* your genes influence how much you eat.

So, let’s talk about some basic genetic concepts and how they are involved with body weight regulation.

P.S. My new book ‘Everything Fat Loss’ is currently on sale at Amazon with an additional 10% and 22% discount in the .com and .co.uk markets. Feel free to grab it before the price goes up.

References:
– The body-mass index of twins who have been reared apart
– A twin study of human obesity
– New advances in the genetics of early onset obesity
– Positional cloning of the mouse obese gene and its human homologue
– Congenital leptin deficiency is associated with severe early-onset obesity in humans
– Lessons from extreme human obesity: monogenic disorders
– The genetics of obesity: from discovery to biology
– Variability in the heritability of body mass index: a systematic review and meta-regression
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View full lesson: http://ed.ted.com/lessons/how-the-choices-you-make-can-affect-your-genes-carlos-guerrero-bosagna

Here’s a conundrum: Identical twins originate from the same DNA … so how can they turn out so different — even in traits that have a significant genetic component? Carlos Guerrero-Bosagna explains that while nature versus nurture has a lot to do with it, a deeper, related answer can be found within something called epigenetics.

Lesson by Carlos Guerrero-Bosagna, animation by Chris Bishop.
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#Genetics #MachineLearning #DataScience

In this episode, Dr. Jonathan Flint, Professor of Psychiatry and Biobehavioral Sciences at the University of California Los Angeles, joins us to discuss how he uses data science and machine learning to explore the link between genetics and depression.

This episode is brought to you by Monte Carlo, the data observability leaders, and by UC Irvine master of data science program at the University of California.

In this episode you will learn:
• Johnathan’s background [0:53]
• How we know that genetics plays a role in complex human behaviors including psychiatric disorders like anxiety, depression, and schizophrenia [5:58]
• The role that data science and ML play in modern genetics research [13:03]
• About Jonathan book “How Genes Influence Behavior” [17:38]
• The day-to-day life of a world-class medical sciences researcher [30:18]
• The open-source software libraries that Jonathan uses for data modeling [38:26]
• A single question you can ask to prevent a severely depressed person from committing suicide [49:55]
• LinkedIn Q&A [52:35]
• The future of psychiatric treatments [1:03:24]

Additional materials: https://www.superdatascience.com/547

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